Induction of the inflammasome by the SARS-CoV-2 accessory protein ORF9b, abrogated by small-molecule ORF9b homodimerization inhibitors
Erika Zodda, Mònica Pons, Natàlia DeMoya‐Valenzuela, Cristina Calvo‐González, Cristina Benítez‐Rodríguez, Blanca D. López‐Ayllón, Achraf Hibot, Alice Zuin, Bernat Crosas, Marta Cascante, María Montoya, María Dolors Pujol, Jaime Rubio‐Martínez, Timothy M. Thomson
This study shows that SARS-CoV-2's ORF9b protein activates inflammasomes and caspase-1, and small molecules inhibiting its homodimerization reduce inflammation and restore interferon signaling.
Journal of Medical Virology · Feb 1, 2025Peer-reviewedMicrobiology