Metabolically Activated Proteostasis Regulators Reduce Differentiation of CD4+ TH17 Cells
Priyadarshini Chatterjee, Keishla Sánchez Ortiz, Stanislav Dikiy, Michael J. Bollong, Jessica E. Thaxton, Alejandra Mendoza, R. Luke Wiseman
This study shows that AA147, a metabolically activated proteostasis regulator, reduces TH17 cell differentiation by degrading RORgammat and IRF4, and dampens effector cytokine responses across T cell subsets.
bioRxiv · Sep 5, 2026 · PreprintCell Biology