Priyadarshini Chatterjee

This study shows that AA147, a metabolically activated proteostasis regulator, reduces TH17 cell differentiation by degrading RORgammat and IRF4, and dampens effector cytokine responses across T cell subsets.

This study identifies potent PDIA1 inhibitors that block NLRP3 inflammasome activity without significant cellular toxicity, offering a strategy to treat diseases involving hyperactive NLRP3.