Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils
Hayato Etani, Sho Takatori, Wenbo Wang, Jumpei Omi, Yusuke Amiya, Aika Akahori, Hirotaka Watanabe, Iki Sonn, Hideyuki Okano, Norikazu Hara, Mai Hasegawa, Akinori Miyashita, Masataka Kikuchi, Takeshi Ikeuchi, Maho Morishima, , Taisuke Tomita
This study identifies GPR34 as a regulator of microglial amyloid β fibril uptake, showing that its agonist enhances fibril clearance and that its expression declines with age and AD progression.
Alzheimer s Research & Therapy · Nov 20, 2025Peer-reviewedNeuroscience