Michael J. Federle

This paper identifies and characterizes a novel pigment produced by Streptococcus pyogenes under specific culture conditions and explores its potential biological functions.

This paper identifies a teichoic acid-like cell wall modification in Streptococcus pyogenes that mediates immune suppression and is regulated by quorum sensing.

This study analyzes genomic and transcriptomic data from Streptococcus pyogenes during acute infection and post-treatment carriage, finding distinct gene expression patterns but no carrier-specific genotypes.

This study investigates how Tryglysin A, a RaS-RiPP produced by Streptococcus, affects ex-vivo oral microbiomes and identifies key culturing factors for these systems.

This study investigates how quorum-sensing-active Streptococcus pyogenes suppresses macrophage inflammation at the nuclear level through transcriptomic and phosphoproteomic analyses.