Alexander R. Horswill

A teichoic acid-like wall modification associated with immune suppression is socially regulated in Streptococcus pyogenes

This paper identifies a teichoic acid-like cell wall modification in Streptococcus pyogenes that mediates immune suppression and is regulated by quorum sensing.

Collagen binding adhesin restricts Staphylococcus aureus skin infection

This study shows that collagen binding adhesin (Cna) in Staphylococcus aureus reduces skin infection severity by binding to C1q and limiting inflammation.

Global genome analysis identifies glycolipids and lipoteichoic acid alanylation as contributors to Group B streptococcal diabetic wound infection

The paper identifies glycolipids and lipoteichoic acid alanylation as factors contributing to Group B streptococcal diabetic wound infection using a transposon mutant screen in a murine model.

Matrix porosity is associated with Staphylococcus aureus biofilm survival during prosthetic joint infection

This study shows that Eap proteins in S. aureus biofilms reduce porosity and prevent macrophage invasion, enhancing biofilm survival during prosthetic joint infections.

Polymicrobial interactions between Staphylococcus aureus and Pseudomonas aeruginosa promote biofilm formation and persistence in chronic wound infections

This study shows that Pseudomonas aeruginosa proteases cleave SasG in Staphylococcus aureus to induce aggregation and biofilm formation in chronic wound co-infections.

Androgens at the skin surface regulate S. aureus pathogenesis through the activation of agr quorum sensing

This study shows that androgens like testosterone promote S. aureus pathogenesis by activating the agr quorum sensing system, leading to increased virulence and skin infection.