Hiroshi Matsuo

This study designs and tests optimized oligonucleotide inhibitors for APOBEC3 enzymes, showing improved potency and nuclease stability compared to previous inhibitors.

This study reports the purification of SARS-CoV-2 N protein and its crystal structure in complex with ssDNA, revealing insights into nucleocapsid assembly and DNA-binding residues.

The paper identifies a chemical scaffold targeting hRpn13, revealing a DEUBAD-lacking isoform upregulated in multiple myeloma and demonstrating its potential as a therapeutic target.