Author

Xiuxiu Lu

National Institutes of HealthORCID 0000-0002-9591-7334Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Kylie J. WaltersiD· 2 shared Raj ChariiD· 2 shared Sergey G. TarasoviD· 2 shared Xiang CheniD· 2 shared Anthony M. CianconeiD· 1 shared Bao Quoc TraniD· 1 shared Caroline FromontiD· 1 shared Charles D. SchwietersiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

Kylie J. WaltersORCID

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2 papers

Recent·Most cited

Structures of dynamic interactors at native proteasomes by PhIX-MS and cryoelectron microscopy

Kitaik Lee, Hitendra Negi, Xiang Chen, Katerina Atallah-Yunes, Sunny Truslow, Rithik E. Castelino, Mary R. Guest, Anthony M. Ciancone, Xiuxiu Lu, Sergey G. Tarasov, Raj Chari, Kylie J. Walters, Francis J. O’Reilly

The paper uses PhIX-MS and cryo-EM to map transient interactions at proteasomes, revealing structural details of proteins like TXNL1 and PSMD5.

Molecular Cell · Jul 21, 2026Peer-reviewedCell Biology

Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma

Xiuxiu Lu, Venkata R. Sabbasani, Vasty Osei Amponsa, Christine N. Evans, Julianna C. King, Sergey G. Tarasov, Marzena Dyba, Sudipto Das, King C. Chan, Charles D. Schwieters, Sulbha Choudhari, Caroline Fromont, Yongmei Zhao, Bao Quoc Tran, Xiang Chen, , Kylie J. Walters

The paper identifies a chemical scaffold targeting hRpn13, revealing a DEUBAD-lacking isoform upregulated in multiple myeloma and demonstrating its potential as a therapeutic target.

Nature Communications · Dec 16, 2021Peer-reviewedMolecular Biology