TMEM63 proteins act as mechanically-activated cholesterol modulated lipid scramblases contributing to membrane mechano-resilience
Yiechang Lin, Zijing Zhou, Yaoyao Han, Delfine Cheng, Haoqing Jerry Wang, Lining Arnold Ju, Yixiao Zhang, Charles David Cox, Ben Corry
The paper shows TMEM63 proteins function as mechanically activated lipid scramblases, modulated by cholesterol, contributing to membrane resilience.
Nature Communications · Jan 30, 2026Peer-reviewedBiophysics