This study identifies PKA as a key effector of the Moody GPCR in Drosophila BBB formation and maintenance, showing its role in regulating cell growth and junction integrity.

eLife · Aug 12, 2021Peer-reviewedDevelopmental Biology

PI31 expression prevents neuronal degeneration in a mouse Parkinson Disease model

Adi Minis, Hermann Steller

This study shows that PI31 expression in a mouse Parkinson's Disease model prevents neuronal degeneration and extends lifespan.

bioRxiv · May 5, 2020 · PreprintNeuroscience

The proteasome regulator PI31 is required for protein homeostasis, synapse maintenance and neuronal survival in mice

Adi Minis, Jose A. Rodriguez, Avi Levin, Kai Liu, Eve‐Ellen Govek, Mary E. Hatten, Hermann Steller

This study shows that PI31 is essential for neuronal protein homeostasis, synapse maintenance, and survival in mice, with implications for neurodegenerative diseases.

Proceedings of the National Academy of Sciences · Nov 21, 2019Peer-reviewedNeuroscience

Regulation of Numb during planar cell polarity establishment in the Drosophila eye

Pedro Manuel Dias Neto Domingos, Andreas Jenny, Keon F. Combie, David del Álamo, Marek Mlodzik, Hermann Steller, Bertrand Mollereau

This study investigates the role of Numb in regulating Notch signaling during R3/R4 photoreceptor specification and planar cell polarity establishment in the Drosophila eye.

Mechanisms of Development · Nov 2, 2019Peer-reviewedDevelopmental Biology

Axin proteolysis by Iduna is required for the regulation of stem cell proliferation and intestinal homeostasis in Drosophila

Yetiş Gültekin, Hermann Steller

This study shows that Iduna regulates Axin proteolysis, which controls stem cell proliferation and intestinal homeostasis in Drosophila.

Development · Feb 22, 2019Peer-reviewedDevelopmental Biology