Pedro Manuel Dias Neto Domingos

This study shows Fbxo42 promotes degradation of Ataxin-2 granules, enabling Xbp1 translation and triggering cell death during terminal UPR activation.

This study shows that the EMC3 subunit is critical for lipid droplet homeostasis in mice and Drosophila, with loss of EMC3 causing triglyceride storage defects and reduced FITM2 levels.

This study shows that iTAP regulates ADAM17 activity, affecting inflammation, epithelial repair, and tumor growth in mice without causing widespread ADAM17 loss effects.

This study shows that α-synuclein accumulation in presynaptic terminals causes synaptic dysfunction and progressive neurodegeneration in a Drosophila model, with similar findings in patient samples.

This study investigates the role of Numb in regulating Notch signaling during R3/R4 photoreceptor specification and planar cell polarity establishment in the Drosophila eye.

This study identifies highroad as a retinoid-inducible gene that clears mutant Rhodopsin-1 in Drosophila retinal degeneration models.

This study shows that protein phosphatase 1 (PP1) regulates huntingtin exon 1 (HTTex1) aggregation and toxicity by modulating phosphorylation at T3.