Marek Mlodzik

The Wnt co-receptor Arrow-LRP5/6 is required for Planar Cell Polarity establishment in Drosophila

This study shows that the Wnt co-receptor Arrow-LRP5/6 is essential for Planar Cell Polarity (PCP) establishment in Drosophila, correcting the previous notion that PCP signaling operates without co-receptors.

A novel conserved protein associates with the IFT-A complex to mediate nuclear translocation of β-catenin in Wg/Wnt-signaling

This study identifies a novel conserved protein, Pasovec, that interacts with the IFT-A complex to facilitate nuclear translocation of β-catenin in Wg/Wnt signaling.

A Van Gogh/Vangl tyrosine phosphorylation switch regulates its interaction with core Planar Cell Polarity factors Prickle and Dishevelled

The paper shows that phosphorylation of a specific tyrosine in Vang/Vangl regulates its interaction with Pk and Dsh/Dvl, promoting the formation of the Vang/Vangl-Pk complex during PCP establishment.

Notch-dependent Abl signaling regulates cell motility during ommatidial rotation in Drosophila

The paper shows that Abl kinase, regulated by Notch signaling, negatively controls ommatidial rotation in Drosophila by modulating adherens junction dynamics during eye development.

Par3/Bazooka binds NICD and promotes Notch signaling during Drosophila development

This study identifies a novel role for Baz/Par3 in promoting Notch signaling by interacting with NICD during Drosophila development.

Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos

The paper shows Notch signaling regulates ommatidial rotation in Drosophila by upregulating argos, an EGFR ligand, through direct transcriptional control in R4 photoreceptors.

Regulation of Numb during planar cell polarity establishment in the Drosophila eye

This study investigates the role of Numb in regulating Notch signaling during R3/R4 photoreceptor specification and planar cell polarity establishment in the Drosophila eye.