Activation of the protective arm of renin-angiotensin system enhances mitochondrial turnover improving respiration and decreasing integrated stress response in a human Complex III deficiency model.
Lucía Fernández-del-Río, Andrea Eastes, David Rincon Fernandez Pacheco, Nikole Scillitani, Jasmine Garza, Matthew Dugan, Matheus Oliveira, Pradnya Kadam, Iman Gauhar, Karel Erion, Kathleen E. Rodgers, Kevin J. Gaffney, Amy Wang, Marc Liesa, Cristiane Benincá, Orian S. Shirihai
This paper shows that activating the MasR receptor with CAP-1902 improves mitochondrial function in a human Complex III deficiency model by enhancing turnover and reducing stress.
bioRxiv · Mar 25, 2026 · PreprintCell Biology