Author

Fabian‐Xosé Fernandez

University of ArizonaORCID 0000-0002-4288-5383Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Donna K. KlinedinstiD· 2 shared Roger H. ReevesiD· 2 shared Alena V. SavonenkoiD· 1 shared Angel C Leslie· 1 shared Anna J. MoyeriD· 1 shared Bei Cheng· 1 shared Benjamin DevenneyiD· 1 shared Carolina Figueroa· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersGenetics

Donna K. KlinedinstORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintMar 14, 2026

HLA-DRB1*15:01 drives sex- and age-dependent microglial activation and neuroimmune signaling

Elsa M. Reyes‐Reyes, Dhanalakshmi Chinnasamy, Fabian‐Xosé Fernandez…·Kathleen E. Rodgers

This study shows that HLA-DRB1*15:01 causes age- and sex-dependent microglial activation and neuroimmune signaling changes linked to cognitive impairment and inflammation in the CNS.

DOI 10.64898/2026.03.11.711132

mouseexperimental assay

𝕏 PostBluesky

GeneticsDisease Models & MechanismsPeer-reviewedMar 30, 2023

Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome

Anna J. Moyer, Fabian‐Xosé Fernandez, Yicong Li…·Roger H. Reeves

The paper identifies multiple chromosome 21 genes that modulate Sonic hedgehog signaling, which is dysregulated in Down syndrome.

17 citationstop 3%

mousehuman

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NeuroscienceActa Neuropathologica CommunicationsPeer-reviewedAug 16, 2021

Forebrain Shh overexpression improves cognitive function in a Down syndrome mouse model and euploid littermates

Feng Gao, Donna K. Klinedinst, Fabian‐Xosé Fernandez…·Roger H. Reeves

This study shows that overexpressing Shh in the forebrain of Down syndrome mice improves cognitive function, while cerebellar Shh overexpression does not.

14 citations

mouseexperimental assay

𝕏 PostBluesky