Marc Liesa

A transient pulse of neuronal ATF4 installs a durable non-autonomous programme promoting healthy ageing

This study shows that transient ATF4 activation in neurons during early adulthood extends healthspan and promotes systemic adaptations in Drosophila.

Pdk1-dependent metabolic heterogeneity promotes aggressive colorectal cancer through cell-intrinsic interferon signaling

This study identifies Pdk1-high metabolic cancer cells in colorectal tumors that drive aggressive behavior through interferon signaling.

Activation of the protective arm of renin-angiotensin system enhances mitochondrial turnover improving respiration and decreasing integrated stress response in a human Complex III deficiency model.

This paper shows that activating the MasR receptor with CAP-1902 improves mitochondrial function in a human Complex III deficiency model by enhancing turnover and reducing stress.

The malate aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

This study shows the malate aspartate shuttle supports lipid mobilization in brown adipocytes by regulating lipid homeostasis and thermogenesis.

A cold-inducible phospholipid--protein interaction in brown fat mitochondria optimizes thermogenic capacity

The paper identifies LPCAT3 as a cold-regulated enzyme that generates AA-PE in BAT mitochondria, enhancing ETC efficiency and thermogenesis.

Single cell profiling of the VMH reveals a sexually dimorphic regulatory node of energy expenditure

The paper identifies six distinct neuron clusters in the VMH using single-cell RNA sequencing and shows sex-specific differences in gene expression and function related to energy expenditure.

GPS2 regulates mitochondria biogenesis via mitochondrial retrograde signaling and chromatin remodeling of nuclear-encoded mitochondrial genes

This study identifies GPS2 as a mediator of mitochondrial retrograde signaling and a key activator of nuclear-encoded mitochondrial genes, revealing a novel mitochondria-nuclear communication pathway.