Rita Bottino

This paper develops a 3D bioprinting method using decellularized extracellular matrix-enriched bioinks to create functional human islet constructs for beta-cell replacement therapy in type 1 diabetes.

The paper maps the morphological and functional maturation of human endocrine pancreas from birth to age 10 using pediatric tissue samples and imaging techniques.

This paper demonstrates that expressing human sialyltransferase in pigs reduces immune rejection by altering sialic acid linkages, improving xenotransplantation outcomes.

The paper identifies combinatorial transcription factor expression in human islet cells and shows it correlates with functional maturity and electrophysiological activity.

The paper uses single nucleus and in situ RNA sequencing to create a comprehensive atlas of human pancreas cells, revealing cell topographies and differences between adult and neonatal pancreata.

This study shows TEAD1 regulates adult β-cell proliferation and function, maintaining glucose homeostasis by balancing quiescence and mature identity in mice and humans.

This study investigates pig pancreatic islet development, identifying similarities with human islet ontogeny and uncovering signaling pathways relevant to beta-cell maturation.

This study uses single-cell RNA-seq to analyze human pancreatic cells across age, identifying transcriptional instability and age-related mutational signatures linked to oxidative stress.