Hans Michael Maric

Cryo-EM Structures of Higher Order Gephyrin OligomersReveal Principles of Inhibitory Postsynaptic Scaffold Organization

This study determines the structure of higher-order gephyrin oligomers using cryo-EM, revealing how its flexible linker regulates receptor binding and oligomerization.

Aggregation-Dependent Epitope Sequence and Modification Fingerprints of Anti-Aβ Antibodies

This study characterizes the binding and modification requirements of 20 anti-Aβ antibodies across different Aβ forms, revealing aggregation-dependent sequence and modification selectivity.

Competition between glycine and GABAA receptors for gephyrin controls their equilibrium populations at inhibitory synapses

The paper investigates competition between glycine and GABA receptors for gephyrin at inhibitory synapses using single-molecule techniques and molecular tweezers, revealing thermodynamic properties and implications for synaptic plasticity.

Distinct myeloid precursors and their interaction with mesenchymal cells orchestrate the spreading of psoriatic disease from the skin to the joints

The paper identifies a unique myeloid precursor population that facilitates the spread of psoriatic inflammation from skin to joints, interacting with fibroblasts to regulate T cell IL-17 expression.

Nanobinders for Synaptotagmin 1 enable the analysis of synapticvesicle dynamics in rodent and human models.

The paper introduces NbLumSyt1 nanobinders for analyzing synaptic vesicle dynamics in rodent and human models with improved precision and versatility.

RNA-mediated MYC multimerization suppresses innate immune signaling

This study shows that MYC multimerization driven by RNA binding suppresses innate immune signaling by promoting exosome recruitment to R-loops and preventing immunogenic RNA accumulation.

Induction of Hepatitis B Core Protein Aggregation Targeting an Unconventional Binding Site

This study identifies two binding sites on the HBV capsid and demonstrates peptides that induce HBc aggregation in vitro and in cells.

Sylites: Multipurpose markers for the visualization of inhibitory synapses

The paper introduces Sylites, fluorogenic probes for visualizing inhibitory synapses with high contrast and selectivity, enabling precise nanoscopic measurements and 3D distribution analysis in brain tissue.

Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes

The paper shows that YAP interacts with the MMB complex to regulate cardiomyocyte proliferation through shared control of cell cycle genes.