Author

Mariana Lopez Leon

Harvard UniversityORCID 0000-0002-4599-7719Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Peter Karl SorgeriD· 2 shared Roxanne J. PelletieriD· 2 shared Anne ZarembaiD· 1 shared Antje SuckeriD· 1 shared Baby Anusha SatravadaiD· 1 shared Bastian SchillingiD· 1 shared Bojan KarlašiD· 1 shared Carola BerkingiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Peter Karl SorgerORCID

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2 papers

Recent·Most cited

Multiomic profiling of a unique in-transit melanoma cohort identifies melanoma differentiation as predictor of tumor progression and therapy response

Giuseppe Tarantino, Anne Zaremba, Tuulia Vallius, Mark Woodnorth, Yichao Hua, Roxanne J. Pelletier, Mariana Lopez Leon, Yingxiao Shi, Zoltan Maliga, Samira Makhzami, Tyler J. Aprati, Bojan Karlaš, Valerie Glutsch, Bastian Schilling, Jessica C. Hassel, , Dirk Schadendorf

The paper identifies melanoma differentiation and immune exhaustion as predictors of tumor progression and therapy response in in-transit melanoma patients through multiomic profiling.

bioRxiv · Oct 1, 2025 · PreprintCancer Biology

Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma

Tanjina Kader, Jia‐Ren Lin, Clemens B. Hug, Shannon Coy, Yu‐An Chen, Ino de Bruijn, Natalie N. C. Shih, Euihye Jung, Roxanne J. Pelletier, Mariana Lopez Leon, Gabriel Mingo, Dalia K. Omran, Jong Suk Lee, Clarence Yapp, Baby Anusha Satravada, , Sandro Santagata

This study uses spatial profiling to show immune suppression and microenvironment changes in fallopian tube precursors of high-grade serous ovarian cancer.

Cancer Discovery · Dec 20, 2024Peer-reviewedCancer Biology