Dirk Schadendorf

This paper identifies 116 risk loci for melanoma through GWAS, links susceptibility to immunity and Wnt signaling, and develops a PRS improving risk prediction.

The paper identifies melanoma differentiation and immune exhaustion as predictors of tumor progression and therapy response in in-transit melanoma patients through multiomic profiling.

This study shows that constitutive IκBζ expression in melanoma promotes tumor growth and immunotherapy resistance by suppressing cytokine production and immune cell recruitment.

The paper identifies tertiary lymphoid structures in brain metastases from different cancer types and links their presence to patient survival.

This study identifies KDM5B's role in regulating the PRDX/TXN ROS detoxification system in melanoma DTPs, showing that PRDX inhibition increases ROS vulnerability and delays resistance to MAPK inhibition.

The paper uses Perturb-CITE-Seq to identify novel immune evasion mechanisms in cancer by analyzing multi-modal single-cell data from patient-derived models.

This paper identifies novel pleiotropic risk loci for melanoma and nevus density, implicating multiple biological pathways and gene expression under MITF regulation.