Mitochondrial control of fuel switching via carnitine biosynthesis
Christopher Auger, Hiroshi Nishida, Bo Yuan, Guilherme Martins Silva, Masanori Fujimoto, Mark Li, Daisuke Katoh, Dandan Wang, Melia Granath-Panelo, Jihoon Shin, Rose Witte, Jin-Seon Yook, Anthony R.P. Verkerke, Alexander S. Banks, Sheng Tony Hui, , Shingo Kajimura
SLC25A45 is the inner mitochondrial membrane transporter for trimethyllysine required for de novo carnitine biosynthesis, enabling metabolic fuel switching to fatty acid oxidation during cold exposure and semaglutide treatment.
Science · Jan 8, 2026Peer-reviewedBiochemistry✦ In-depth digest