Sheng Tony Hui

The paper identifies adaptive pathways in hepatocytes that restore homeostasis during lipid overload by coordinating fatty acid oxidation and suppression of unsaturated fatty acid synthesis.

SLC25A45 is the inner mitochondrial membrane transporter for trimethyllysine required for de novo carnitine biosynthesis, enabling metabolic fuel switching to fatty acid oxidation during cold exposure and semaglutide treatment.

The paper links lower plasma plasmalogen levels to increased risk of lymph node positive breast cancer in humans and mice, showing dietary PUFA depletion promotes cancer survival in lymph nodes.

This study identifies a cholesterol-responsive interaction between NFE2L1 and INSIG1 that sustains cholesterol balance and prevents MASH by promoting VLDL secretion.

This study identifies sustained glucose turnover flux as a distinguishing metabolic feature of cancer cachexia compared to nutrient limitation under controlled food intake.

This study investigates the extent to which anorexia contributes to different cachectic phenotypes in cancer cachexia using a preclinical model.

The paper develops an organism-level quantitative flux model of energy metabolism in mice by integrating isotope tracing and mass spectrometry, revealing distinct metabolic cycling and oxidation flux patterns for circulating nutrients.

This study shows that peroxisomal dysfunction during aging reduces metabolic flexibility by impairing mitochondrial dynamics and nutrient responses, which can be mitigated by dietary restriction.

This study quantifies metabolic fluxes of circulating metabolites in mice using isotope tracing and mass spectrometry to identify major metabolic cycles and their tissue-specific contributions.