ImmunologyThe Journal of ImmunologyPeer-reviewed
Glutamine-Dependent Biosynthetic Pathways Fuel Autoreactive T and B Cells in Foxp3 Deficiency-mediated Disease
Mohammad Adeel Zafar, Charlotte Nicole Hill Machado, Jyotirmaya Behera…·Louis‐Marie Charbonnier
This study shows glutamine supports autoimmune disease in Foxp3 deficiency by fueling biosynthetic pathways in T and B cells, with distinct roles in cytokine production and autoantibody formation.
DOI 10.1172/jci.insight.200076