The paper uses ABC and machine learning to determine that the SLC30A9 rs1047626 polymorphism originated in Denisovans, introgressed into Neanderthals, and then into non-African humans, with differential selection pressures in different populations.

bioRxiv · Sep 28, 2026 · PreprintEvolutionary Biology

Sudan's complex genetic admixture history drives adaptation to malaria in Sudanese Copts

Laura Vilà-Valls, Jorge Garcia-Calleja, Javier Prado-Martinez, Elena Bosch, Aida M. Andrés, M Netea, D. Comas, Hisham Y. Hassan

This study presents the first whole-genome sequencing of Sudanese populations, revealing complex admixture history and adaptive genetic variants related to malaria resistance in Sudanese Copts.

Proceedings of the National Academy of Sciences · Jan 6, 2026Peer-reviewedGenetic & Genomic Medicine

Novel insights into the genetic architecture and mechanisms of host/microbiome interactions from a multi-cohort analysis of outbred laboratory rats

Hélène Tonnelé, Denghui Chen, Felipe Morillo, Jorge Garcia-Calleja, Apurva S. Chitre, Benjamin B. Johnson, Thiago Missfeldt Sanches, Riyan Cheng, Marc Jan Bonder, Antonio González, Tomasz Kościółek, Anthony M. George, Wenyan Han, Katie Holl, Aidan P. Horvath, , Amelie Baud

The paper identifies host genetic effects on microbiome composition in rats and finds evidence of indirect genetic effects contributing to missing heritability.

Nature Communications · Dec 18, 2025Peer-reviewedGenetics