Author

Aidan P. Horvath

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 4 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:GWAS / association mapping· 5 Organism:rat· 5 Approach:statistical model· 5 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:GWAS summary statistics· 1 Assay:metagenomics· 1

Frequent Co-Authors

Abraham A. PalmeriD· 5 shared Apurva S. ChitreiD· 5 shared Christopher P. KingiD· 5 shared Connor D. MartiniD· 5 shared Keita IshiwariiD· 5 shared Oksana PolesskayaiD· 5 shared Paul MeyeriD· 5 shared Riyan ChengiD· 5 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersGenetics

Abraham A. PalmerORCID

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5 papers

Recent·Most cited

Genomic SEM reveals shared genetic architecture and expands locus discovery for locomotor activity in heterogeneous stock rats

Apurva S. Chitre, Thiago Missfeldt Sanches, Gavrila Ang, Nana K. Amissah, Rodolfo Avila, Hannah V. Bimschleger, Paola Campo, Nazzareno Cannella, Denghui Chen, Riyan Cheng, Katarina A Cohen, Ayteria D. Crow, Eric Dereschewitz, Michelle R. Doyle, Maya Eid, , Abraham A. Palmer

The paper uses Genomic SEM to identify loci underlying locomotor activity in rats, finding 31 loci compared to fewer from other methods.

bioRxiv · Oct 6, 2026 · PreprintGenetics

Novel insights into the genetic architecture and mechanisms of host/microbiome interactions from a multi-cohort analysis of outbred laboratory rats

Hélène Tonnelé, Denghui Chen, Felipe Morillo, Jorge Garcia-Calleja, Apurva S. Chitre, Benjamin B. Johnson, Thiago Missfeldt Sanches, Riyan Cheng, Marc Jan Bonder, Antonio González, Tomasz Kościółek, Anthony M. George, Wenyan Han, Katie Holl, Aidan P. Horvath, , Amelie Baud

The paper identifies host genetic effects on microbiome composition in rats and finds evidence of indirect genetic effects contributing to missing heritability.

Nature Communications · Dec 18, 2025Peer-reviewedGenetics

Genomic Loci Influencing Cue-Reactivity in Heterogeneous Stock Rats

Christopher P. King, Apurva S. Chitre, Joel D. Leal‐Gutiérrez, Jordan A. Tripi, Alesa H. Netzley, Aidan P. Horvath, Alexander C. Lamparelli, Anthony M. George, Connor D. Martin, Celine L. St. Pierre, Thiago Missfeldt Sanches, Hannah V. Bimschleger, Jianjun Gao, Riyan Cheng, Khai‐Minh Nguyen, , Paul Meyer

This study identifies genomic loci associated with cue-reactivity in rats, linking them to incentive salience and drug abuse-related traits.

Genes Brain & Behavior · Mar 6, 2025Peer-reviewedNeuroscience

Exponential increase in QTL detection with increased sample size.

Apurva S. Chitre, Oksana Polesskaya, Daniel B. Munro, Riyan Cheng, Pejman Mohammadi, Katie Holl, Jianjun Gao, Hannah V. Bimschleger, Angel Garcia Martinez, Anthony M. George, Alexander F. Gileta, Aidan P. Horvath, Alesa Hughson, Keita Ishiwari, Christopher P. King, , Abraham A. Palmer

The paper simulates GWAS in rats to show that larger sample sizes lead to an exponential increase in the number of significant loci detected.

bioRxiv · Jan 27, 2023 · PreprintGenetics

Genome wide association study in 3,173 outbred rats identifies multiple loci for body weight, adiposity, and fasting glucose

Apurva S. Chitre, Oksana Polesskaya, Katie Holl, Jianjun Gao, Riyan Cheng, Hannah V. Bimschleger, Angel Garcia Martinez, Tony George, Alexander F. Gileta, Wenyan Han, Aidan P. Horvath, Alesa Hughson, Keita Ishiwari, Christopher P. King, Alexander C. Lamparelli, , Leah C. Solberg Woods

Obesity · Aug 29, 2020Peer-reviewedGenetics