Katie Holl

This paper expands the RatGTEx resource with transcriptome-wide associations across 3,160 RNA-seq samples, identifying 7,473 gene-trait links and 144,876 QTLs for 22,599 genes.

The paper identifies host genetic effects on microbiome composition in rats and finds evidence of indirect genetic effects contributing to missing heritability.

RatXcan extends transcriptome-wide association studies to rats, enabling cross-species integration of GWAS and gene expression data to identify shared genetic mechanisms of complex traits.

The paper genotypes Y and mitochondrial chromosomes in heterogeneous stock rats and finds no significant associations with complex traits, except for gene expression on these chromosomes.

The paper simulates GWAS in rats to show that larger sample sizes lead to an exponential increase in the number of significant loci detected.

The paper identifies 554 consensus genes in outbred rats and humans associated with body weight and BMI, revealing shared genetic regulatory mechanisms relevant for obesity.

This study identifies 30 genome-wide significant QTLs for open field behaviors in rats, with 13 candidate genes linked to psychiatric disorders in humans.

The paper identifies regions of potential mis-assembly in the rat reference genome using whole-genome sequencing data from eight inbred strains.