Cancer BiologybioRxivPreprint
Dual targeting of EZH2 and Histone Deacetylases in hematological malignancies promotes transcriptional and metabolic deregulation leading to ferroptosis
Alexandra Bacquelaine Veloso, Thomas Slegers, Jente M. Schoenaker…·Marlies Vanden Bempt
This study shows that targeting EZH2 and HDACs together induces ferroptosis in hematological malignancies by upregulating cholesterol biosynthesis and causing metabolic stress.
DOI 10.1101/2024.03.03.583195