Author

Kris Jacobs

Universitair Ziekenhuis LeuvenORCID 0009-0002-9733-4826Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Heidi SegersiD· 2 shared Jan CoolsiD· 2 shared Lien BoogaertsiD· 2 shared Sofie DemeyeriD· 2 shared Alexandra Bacquelaine VelosoiD· 1 shared Charlien VandersmisseniD· 1 shared Daan DierickxiD· 1 shared Félicien Renard· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCancer Biology

Heidi SegersORCID

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2 papers

Recent·Most cited

Dual targeting of EZH2 and Histone Deacetylases in hematological malignancies promotes transcriptional and metabolic deregulation leading to ferroptosis

Alexandra Bacquelaine Veloso, Thomas Slegers, Jente M. Schoenaker, Sofie Demeyer, Stef Van den Bergh, Margo Aertgeerts, Krista Roberta Verhoeft, Yilke Schoenmaekers, Nienke Meeuws, Ilan Bischops, Félicien Renard, Lien Boogaerts, Nicole Mentens, Olga Gielen, Kris Jacobs, , Marlies Vanden Bempt

This study shows that targeting EZH2 and HDACs together induces ferroptosis in hematological malignancies by upregulating cholesterol biosynthesis and causing metabolic stress.

bioRxiv · Mar 3, 2024 · PreprintCancer Biology

Resistance to PSEN1-selective γ-secretase inhibitors in T-cell acute lymphoblastic leukemia

Charlien Vandersmissen, Sofie Demeyer, Kris Jacobs, Lien Boogaerts, Sara Gutiérrez Fernández, Heidi Segers, Lucía Chávez‐Gutiérrez, Jan Cools

The paper identifies PSEN1 mutations that confer resistance to MRK-560 in T-ALL, revealing three distinct resistance mechanisms.

bioRxiv · Mar 1, 2024 · PreprintCancer Biology