This study identifies consistent sex differences in gut microbiota of MS patients across multiple cohorts, highlighting the importance of sex as a variable in microbiome research.

mSystems · Jul 22, 2026Peer-reviewedNeuroscience

Large-scale association analyses identify host factors influencing human gut microbiome composition

Alexander Kurilshikov, Carolina Medina‐Gómez, Rodrigo Bacigalupe, Djawad Radjabzadeh, Jun Wang, Ayşe Demirkan, Caroline Ivanne Le Roy, Juan A. Raygoza Garay, Casey T. Finnicum, Xingrong Liu, Daria V. Zhernakova, Marc Jan Bonder, Tue H. Hansen, Fabian Frost, Malte Christoph Rühlemann, , Oluf Borbye Pedersen

The paper identifies 31 host genetic loci influencing gut microbiome composition through GWAS and suggests causal effects in inflammatory diseases.

Nature Genetics · Jan 18, 2021Peer-reviewedGenetics

Microbiome Determinants and Physiological Effects of the Benzoate-Hippurate Microbial-Host Co-Metabolic Pathway

François Brial, Julien Chilloux, Trine Nielsen, Sara Vieira‐Silva, Gwen Falony, Lesley Hoyles, Ana Luísa Neves, Andrea Rodriguez‐Martinez, Ghiwa Ishac Mouawad, Nicolas Pons, Sofia Kirke Forslund, Emmanuelle Le Chatelier, Aurélie Le Lay, Jeremy Kirk Nicholson, Torben F. Hansen, , Marc‐Emmanuel Dumas

This study identifies microbiome determinants of hippurate, a metabolite linked to metabolic health, and demonstrates its protective effects in mice through benzoate-hippurate pathway analysis.

bioRxiv · Dec 15, 2019 · PreprintSystems Biology