Alejandro Arias Vásquez

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

The paper conducts GWAS on brain volumes, identifies genetic loci, and develops polygenic scores with cross-ancestry predictive ability and causal links to neuropsychiatric disorders.

A comparison of bioinformatics pipelines for compositional analysis of the human gut microbiome

This paper compares five bioinformatics pipelines for analyzing 16S rRNA gene sequencing data from the gut microbiome, showing how pipeline choice affects downstream statistical results and case-control conclusions.

Genetic background of grey matter brain networks related to attention-deficit/hyperactivity disorder

The paper identifies ten genes associated with ADHD-related grey matter brain networks in a sample of 899 individuals.

Dissecting the heterogeneous subcortical brain volume of Autism spectrum disorder (ASD) using community detection

This study uses community detection to identify subgroups in ASD based on subcortical brain volumes, revealing more homogeneous groups with enhanced case/control differences.

Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes

This study identifies neuroanatomic subgroups in ADHD using subcortical volumes, finding distinct patterns in males but not females.

Large-scale association analyses identify host factors influencing human gut microbiome composition

The paper identifies 31 host genetic loci influencing gut microbiome composition through GWAS and suggests causal effects in inflammatory diseases.

Multivariate associative patterns between the gut microbiota and large-scale brain network connectivity

The paper uses LICA to identify multivariate associations between gut microbiota and brain network connectivity in healthy females, finding specific microbial genera linked to brain network strength.

Quantitative Genetic Scoring, or how to put a number on an arbitrary genetic region

This paper introduces quantitative genetic scoring (QGS) to create quantitative genetic variables from arbitrary regions, showing it can reduce genetic data by >98% while explaining phenotypic variance across different granularities.

Shared genetic background between children and adults with attention deficit/hyperactivity disorder

This study identifies nine new genetic loci associated with ADHD and shows shared genetic architecture between childhood and adult ADHD.

Intellectual Disability-related genes increase ADHD risk and locomotor activity in Drosophila

This study identifies ADHD risk genes by linking ID-related genes to ADHD through common variants and validates their role in Drosophila behavior.

Cross-disorder genetic analyses implicate dopaminergic signaling as a biological link between Attention-Deficit/Hyperactivity Disorder and obesity measures

This study identifies dopaminergic signaling as a genetic link between ADHD and obesity through genome-wide analyses and brain volume associations.

Structural Brain Alterations and Their Association with Cognitive Function and Symptoms in Attention-Deficit/Hyperactivity Disorder Families

The paper identifies structural brain network alterations in ADHD and their association with symptoms and cognitive function using source-based morphometry in a family cohort.

Genetic markers of ADHD-related variations in intracranial volume

The paper identifies genetic correlations between ADHD and brain volumes, finding negative associations with intracranial volume and specific brain regions.

Stress matters: a double-blind, randomized controlled trial on the effects of a multispecies probiotic on neurocognition

This study investigates the effects of a multispecies probiotic on neurocognition in healthy volunteers, finding it improves working memory under stress but not emotion regulation or cognitive control.

A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

This study investigates genetic mechanisms underlying sex bias in ADHD prevalence using genome-wide data and finds no mean polygenic burden difference across sexes but increased risk in female siblings and comorbid conditions.

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

The paper identifies 25 genetic loci associated with subcortical brain structure volumes in over 40,000 individuals, revealing novel biology and potential drug targets.