Gene therapy targeting of AKAP6β-CaMKII signalosomes improves myocardial inflammation and heart failure in a swine model of cardiometabolic syndrome
Darla L. Tharp, Sofia M. Possidento, Jinliang Li…·Michael S. Kapiloff
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UConn HealthORCID 0000-0002-4622-2720Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Darla L. Tharp, Sofia M. Possidento, Jinliang Li…·Michael S. Kapiloff
Moriah Gildart Turcotte, Anne‐Maj Samuelsson, Sofia M. Possidento…·Kimberly L. Dodge‐Kafka
This study identifies Golgi-localized β-adrenergic receptors as critical for cAMP and calcium signaling, pathological gene transcription, and cardiomyocyte hypertrophy, offering a new therapeutic target for Dilated Cardiomyopathy.
Anne‐Maj Samuelsson, Abraham L. Bayer, Jinliang Li…·Michael S. Kapiloff
This paper shows that targeting CIP4-CaNAβ2 signalosomes improves cardiac function and reduces remodeling after myocardial infarction in mice.