Raul Andino

The paper identifies immune cell activation patterns associated with rapid clearance of infectious SARS-CoV-2 in both unvaccinated and vaccinated individuals.

The paper develops a genetically encoded reporter to detect IFN responses in brain and peripheral tissues, revealing coordinated responses in neurons and non-neuronal cells across various conditions.

This study shows that IFN-β is critical for survival from ECTV and WNV infections, while IFN-α and other subtypes have distinct roles in controlling viral spread and organ protection.

This study examines how pre-existing neutralizing antibodies affect viral shedding in post-vaccination SARS-CoV-2 infections, finding that higher titers reduce viral load and duration but are less effective against Omicron variants.

This study identifies a Type I interferon-responsive microglial subset that engulfs neurons during brain development and shows its role in shaping cortical structure and behavior.

This study introduces dicistrovirus IRESs into UAS/SV40-polyA constructs in Drosophila, leading to premature polyadenylation and enhanced overexpression of upstream ORFs.

The paper develops a fluorescent reporter system to monitor the integrated stress response in live Drosophila, revealing tissue-specific stress regulation during infections.

The paper describes a method to enhance transgene expression in Drosophila melanogaster by preventing mRNA degradation through specific sequences.

This study identifies ribotoxic collisions on CAG expansions as a mechanism causing proteostasis disruption and stress responses in Huntington's Disease.

The paper models the competition between poliovirus and defective interfering genomes, finding DI replicates faster but establishes an equilibrium with WT, reducing WT virion concentration by 5x.

The paper characterizes an antiviral immunity pathway in mosquitoes that uses endogenous viral elements for long-term protection and self-nonself discrimination.

This study shows that poliovirus recombination is important for pathogenesis in animals but detrimental to replication in tissue culture, suggesting recombination aids viral spread within hosts.

This study proposes that lifespan setpoints evolve to protect populations from epidemic risks by limiting individual lifespans, which reduces pathogen spread and enhances population resilience.

The paper characterizes the genomic structure and function of endogenous viral elements (EVEs) in the Aedes aegypti Aag2 cell line using long-read sequencing, revealing their role in antiviral immunity.