Boyu Lyu

AQuA2-Cloud: a web platform for fluorescence bioimaging activity analysis

AQuA2-Cloud provides a web platform for analyzing fluorescence bioimaging data, enabling cloud-based activity quantification with improved accessibility and usability compared to the original AQuA2 tool.

Mitochondrial fission controls astrocyte morphogenesis and organization in the cortex

This study shows that mitochondrial fission is essential for astrocyte morphogenesis and organization in the cortex, with Drp1 loss causing morphological and functional deficits.

Integrated temporal profiling of iPSCs-derived motor neurons from ALS patients carrying C9orf72, FUS, TARDBP, and SOD1 mutations

This study profiles temporal RNA-seq in iPSC-derived motor neurons from ALS patients with specific mutations, identifying shared gene expression and splicing defects across different mutations.

SynQuant: An Automatic Tool to Quantify Synapses from Microscopy Images

SynQuant quantifies synapses from microscopy images by addressing antibody specificity, brightness heterogeneity, and noise, showing improved performance over existing tools in disease models.

Deep Learning Based Tumor Type Classification Using GeneExpression Data

This paper classifies 33 tumor types using deep learning on RNA-Seq data, achieving 95.59% accuracy, higher than GA/KNN, and validates tumor-specific biomarkers through heat-map analysis.