Yipei Song

Gene-by-Sleep Duration Interaction for Glycemic Traits in over 480,000 Individuals

The paper identifies 16 genetic loci interacting with sleep duration to influence glycemic traits in over 480,000 individuals, revealing distinct biological mechanisms for short and long sleep.

Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis

This study performs a meta-analysis of scRNA-seq datasets to map human atherosclerosis cell diversity and identifies disease-relevant vascular cell states and markers.

FHL5 controls vascular disease-associated gene programs in smooth muscle cells

This study identifies FHL5 as a causal gene for vascular disease risk through eQTL colocalization and functional analyses, showing its role in vascular remodeling and calcification.

Cell-specific chromatin landscape of human coronary artery resolves regulatory mechanisms of disease risk

The paper uses single-cell ATAC-seq to analyze coronary artery cells from CAD patients, identifying regulatory mechanisms and risk variants associated with disease.

Single-cell RNA-seq analysis of human coronary arteries using an enhanced workflow reveals SMC transitions and candidate drug targets

The paper applies an enhanced scRNA-seq workflow to human coronary artery data, revealing SMC transitions and drug targets through ligand-receptor analysis and an interactive web tool.