Longitudinal Analysis of Matched Patient Biospecimens Reveals Neural Reprogramming of Cancer-Associated Fibroblasts Following Chemotherapy in Pancreatic Cancer
Aylin Z. Henstridge, Peter A. Azorsa, Nandini Arya, Ahmed M. Elhossiny, Padma Kadiyala, Molly Goldwasser, Georgina Branch, Vaibhav Sahai, Nicole Peterson, Jorge D. Machicado, Richard S. Kwon, Allison R. Schulman, Erik‐Jan Wamsteker, George Philips, Stacy B. Menees, , Eileen S. Carpenter
The paper analyzes matched pre- and post-chemotherapy biospecimens in pancreatic cancer, revealing that cancer-associated fibroblasts undergo neural reprogramming, characterized by axonal guidance gene enrichment, which may contribute to chemoresistance and tumor progression.
Cancer Research · Sep 21, 2026Peer-reviewedCancer Biology