Mitochondrial complex I deficiency occurs in skeletal muscle of a subgroup of individuals with Parkinson's disease
Simon Ulvenes Kverneng, Kjersti Eline Stige, Haakon Berven, Sepideh Mostafavi, Katarina Lundervold, Michele Brischigliaro, Brage Brakedal, Geir Olve Skeie, Irene Hana Flønes, Lilah Toker, Erika Fernández‐Vizarra, Ragnhild Eide Skogseth, Kristoffer Haugarvoll, Yamila N. Torres Cleuren, Christian Dölle, , Charalampos Tzoulis
The paper investigates mitochondrial complex I deficiency in Parkinson's disease muscle biopsies, finding 9% of cases show reduced CI activity without mtDNA abnormalities.
Communications Medicine · Apr 27, 2025Peer-reviewedNeuroscience