Gonzalo S. Nido

The paper investigates mitochondrial complex I deficiency in Parkinson's disease muscle biopsies, finding 9% of cases show reduced CI activity without mtDNA abnormalities.

This study identifies two subtypes of idiopathic Parkinson's disease based on mitochondrial complex I deficiency, with distinct molecular and clinical features.

The paper investigates how POLG genotype affects mitochondrial dysfunction in iPSC-derived neural progenitors, finding greater impairment in compound heterozygous lines compared to homozygous ones.

This study uses ultra-deep whole genome bisulfite sequencing to analyze mtDNA methylation in human brain tissue, identifying a single CpG site with significant methylation and correlating it with mtDNA transcript levels.

The paper identifies genome-wide dysregulation of histone acetylation in Parkinson's disease brains, linking it to disease-related genes and altered gene expression.

This study shows that common gene expression signatures in Parkinson’s disease are driven by changes in cell composition rather than true biological changes.