Lilah Toker

The paper investigates mitochondrial complex I deficiency in Parkinson's disease muscle biopsies, finding 9% of cases show reduced CI activity without mtDNA abnormalities.

This study identifies two subtypes of idiopathic Parkinson's disease based on mitochondrial complex I deficiency, with distinct molecular and clinical features.

The paper identifies genome-wide dysregulation of histone acetylation in Parkinson's disease brains, linking it to disease-related genes and altered gene expression.

This study shows that common gene expression signatures in Parkinson’s disease are driven by changes in cell composition rather than true biological changes.

This study assesses patch-seq, showing technical artifacts in single-cell transcriptomes and proposing a marker gene-based approach to improve gene expression-electrophysiological feature alignment.

The paper compiles a database of mouse brain cell type-specific gene expression profiles, identifies novel marker genes, and demonstrates their use in analyzing bulk tissue data.

The paper identifies 420 genes whose expression correlates with electrophysiological parameters in neurons, suggesting general principles linking gene expression to functional diversity.

The paper identifies widespread sample mislabeling in transcriptomics studies by comparing sex annotations with gene expression data, finding 46% of datasets have mislabeled samples.