Author

Ole‐Bjørn Tysnes

Haukeland University HospitalORCID 0000-0002-7230-6426Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 5 Research Focus:differential expression· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Guido Werner AlvesiD· 5 shared Charalampos TzoulisiD· 4 shared Gonzalo S. NidoiD· 4 shared Christian DölleiD· 3 shared Lilah TokeriD· 3 shared Kristoffer HaugarvolliD· 2 shared Aaron Day-Williams· 1 shared Alastair John NoyceiD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersNeuroscience

Guido Werner AlvesORCID

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Author profile →

5 papers

Recent·Most cited

Mitochondrial complex I deficiency stratifies idiopathic Parkinson's disease

Irene Hana Flønes, Lilah Toker, Dagny Ann Sandnes, Martina Castelli, Sepideh Mostafavi, Njål Gjærde Lura, Omnia Shadad, Erika Fernández‐Vizarra, Cèlia Painous, Alexandra Pérez‐Soriano, Yaroslau Compta, Laura Molina‐Porcel, Guido Werner Alves, Ole‐Bjørn Tysnes, Christian Dölle, , Charalampos Tzoulis

This study identifies two subtypes of idiopathic Parkinson's disease based on mitochondrial complex I deficiency, with distinct molecular and clinical features.

Nature Communications · Apr 29, 2024Peer-reviewedNeuroscience

Ultra-deep whole genome bisulfite sequencing reveals a single methylation hotspot in human brain mitochondrial DNA

Romain Guitton, Christian Dölle, Guido Werner Alves, Ole‐Bjørn Tysnes, Gonzalo S. Nido, Charalampos Tzoulis

This study uses ultra-deep whole genome bisulfite sequencing to analyze mtDNA methylation in human brain tissue, identifying a single CpG site with significant methylation and correlating it with mtDNA transcript levels.

Epigenetics · Mar 7, 2022Peer-reviewedGenomics

Genome-wide dysregulation of histone acetylation in the Parkinsons disease brain

Lilah Toker, Gia Tuong Tran, Janani Sundaresan, Ole‐Bjørn Tysnes, Guido Werner Alves, Kristoffer Haugarvoll, Gonzalo S. Nido, Christian Dölle, Charalampos Tzoulis

The paper identifies genome-wide dysregulation of histone acetylation in Parkinson's disease brains, linking it to disease-related genes and altered gene expression.

Molecular Neurodegeneration · May 4, 2021Peer-reviewedGenomics

Common gene expression signatures in Parkinson’s disease are driven by changes in cell composition

Gonzalo S. Nido, Fiona Dick, Lilah Toker, Kjell Petersen, Guido Werner Alves, Ole‐Bjørn Tysnes, Inge Jonassen, Kristoffer Haugarvoll, Charalampos Tzoulis

This study shows that common gene expression signatures in Parkinson’s disease are driven by changes in cell composition rather than true biological changes.

Acta Neuropathologica Communications · Apr 21, 2020Peer-reviewedNeuroscience

Genome-wide association study of Parkinsons disease progression biomarkers in 12 longitudinal patients cohorts

Hirotaka Iwaki, Cornelis Blauwendraat, Hampton L. Leonard, Jonggeol Jeffrey Kim, Ganqiang Liu, Jodi Maple‐Grødem, Jean‐Christophe Corvol, Lasse Pihlstrøm, Marlies van Nimwegen, Samantha J. Hutten, H. Nguyen Khanh-Dung, Jacqueline H. Rick, Shirley W. Eberly, Faraz Faghri, Peggy Auinger, , Mike A. Nalls

This study identifies two genome-wide significant variants associated with Parkinson's disease progression and replicates known risk variants' effects on motor and cognitive decline.

bioRxiv · Mar 27, 2019 · PreprintGenetics