Guido Werner Alves

This study identifies two subtypes of idiopathic Parkinson's disease based on mitochondrial complex I deficiency, with distinct molecular and clinical features.

This study uses ultra-deep whole genome bisulfite sequencing to analyze mtDNA methylation in human brain tissue, identifying a single CpG site with significant methylation and correlating it with mtDNA transcript levels.

The paper identifies genome-wide dysregulation of histone acetylation in Parkinson's disease brains, linking it to disease-related genes and altered gene expression.

This study shows that common gene expression signatures in Parkinson’s disease are driven by changes in cell composition rather than true biological changes.

This study identifies two genome-wide significant variants associated with Parkinson's disease progression and replicates known risk variants' effects on motor and cognitive decline.