Combining MicroED and native mass spectrometry for structural discovery of enzyme-biosynthetic inhibitor complexes
Niko W. Vlahakis, Cameron W. Flowers, Mengting Liu, Matthew P. Agdanowski, Samuel E. Johnson, Jacob A. Summers, Catherine Keyser, Phoebe Russell, Samuel L. Rose, Julien Orlans, Nima Adhami, Yu Chen, Michael R. Sawaya, Shibom Basu, Daniele de Sanctis, , José A. Rodríguez
This paper combines MicroED and native mass spectrometry to determine structures of enzyme-inhibitor complexes and identify high-affinity ligands from crude samples.
bioRxiv · Feb 20, 2025 · PreprintBiophysics