Systematic optimization of Cas12a base editors in wheat and maize using the ITER platform
Christophe Gaillochet, Alexandra Peña Fernández, Vera Goossens, Katelijn D’Halluin, Andrzej Drozdzecki, Myriam Shafie, Julie Van Duyse, Gert Van Isterdael, Camila Gonzalez, Mattias Vermeersch, Jonas De Saeger, Ward Develtere, Dominique Audenaert, David De Vleesschauwer, Frank Meulewaeter, Thomas B. Jacobs
The paper develops an optimized LbCas12a-ABE base editor in wheat and maize using the ITER platform, achieving 40% activity on a GFP reporter through iterative design.
bioRxiv · May 11, 2022 · PreprintSynthetic Biology