Novel small-molecule inhibitors of the protein kinase DYRK: Potential Therapeutic candidates in cancer
Prabhadevi Venkataramani, Elad Elkayam, Ankur Garg, Kai Fan Cheng, Ahmad S. Altiti, Mingzhu He, Khushabu Thakur, Evdokia Michalopoulou, Camila Gonzalez, Christy Felice, Linda Van Aelst, Darryl Pappin, Leemor Joshua‐Tor, Yousef Al-Abed, Nicholas K. Tonks
This study identifies two selective DYRK1A inhibitors, FC-2 and FC-3, which show antitumor effects in glioblastoma models.
bioRxiv · Nov 5, 2025 · PreprintCancer Biology