S. Paisant

A polarized cell system amenable to subcellular resolution imaging of influenza virus infection

This paper describes a 3D cell culture method to study influenza virus infection in polarized cells with subcellular resolution.

The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome

This study shows that host RNA polymerase II's C-terminal domain, along with ANP32, enhances influenza virus polymerase replication activity, suggesting host RNAP II anchors viral transcription and replication.

The RBPome of influenza A virus mRNA reveals a role for TDP-43 in viral replication

The paper identifies RBPs associated with influenza A virus NP mRNA and shows TDP-43's role in viral replication through mRNA binding and polymerase interactions.

Type B and Type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD

This study compares the binding interfaces of influenza B and A polymerases to the host RNA polymerase II CTD, revealing distinct evolutionary adaptations for host range.

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors

The paper develops a sensitive cell-based luciferase assay for high-throughput screening of SARS-CoV-2 nsp5/3CLpro inhibitors and identifies four effective compounds.