The paper compares signaling profiles in SKS and TSC2 deficiency using proteomics, phosphoproteomics, and transcriptomics to show distinct regulatory states.

bioRxiv · May 13, 2026 · PreprintMolecular Biology

Ferrapoptosis: Discovery of a Hybrid Programmed Cell Death

Qiuyun Yang, Yang Chen, Yang Shen, Xiao Zhang, Xianliang Chen, Xinnan Zhao, Ruixuan Yuan, Mingqiang Li, Yang Xu, Xilong Lin, Yihan Sun, Shengyuan Zuo, Xinyang Liu, Zhuo Li, Ying Chen, , Xiameng Chen

This paper defines and validates a new form of cell death called Ferrapoptosis, which combines features of ferroptosis and apoptosis in traumatic brain injury, and identifies Smg7 as a key regulator.

bioRxiv · Nov 25, 2025 · PreprintCell Biology

Hiplot: a comprehensive and easy-to-use web service boosting publication-ready biomedical data visualization

Jianfeng Li, Ben‐Ben Miao, Shixiang Wang, Wei Dong, Houshi Xu, Chenchen Si, Wei Wang, Songqi Duan, Jiacheng Lou, Zhiwei Bao, Hailuan Zeng, Zengzeng Yang, Wenyan Cheng, Fei Zhao, Jianming Zeng, , Mingjie Wang

Hiplot provides a web service with 230+ interactive visualization tools for biomedical data, enabling users to generate publication-ready graphics without advanced expertise.

Briefings in Bioinformatics · Jul 5, 2022Peer-reviewedBioinformatics

Detailed Clinical and Functional Studies of New MTOR Variants in Smith-Kingsmore Syndrome Reveal Deficits of Circadian and Sleep Homeostasis

Andrew C. Liu, Yang Shen, Destino Roman, Hongzhi He, Carolyn R. Serbinski, Lindsey Aschbacher‐Smith, Katherine A. King, Jorge Luis Granadillo, Isabel López, Darcy A. Krueger, Thomas J. Dye, David F. Smith, John B. Hogenesch, Carlos Enrique Prada

This study identifies new MTOR variants in Smith-Kingsmore Syndrome, reveals circadian and sleep deficits, and shows rapamycin treatment can improve symptoms.

medRxiv · Feb 15, 2022 · PreprintGenetic & Genomic Medicine

NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1

Yang Shen, Mehari Endale, Wei Wang, Andrew R. Morris, Lauren J. Francey, Rachel L. Harold, David W. Hammers, Zhiguang Huo, Carrie L. Partch, John B. Hogenesch, Zhao‐Hui Wu, Andrew C. Liu

This study shows NF-κB interacts with BMAL1 to regulate circadian clock function through transcriptional repression at E-box elements.

PLoS Genetics · Nov 22, 2021Peer-reviewedMolecular Biology