David W. Hammers

Functional and structural pathologies in skeletal muscle of a rat model of Duchenne muscular dystrophy

This study generates a rat model of Duchenne muscular dystrophy using CRISPR/Cas9 and evaluates its functional and structural muscle pathologies across different ages.

Dual S100A1 and ARC gene therapy as a treatment for DMD cardiomyopathy

This paper investigates dual S100A1 and ARC gene therapy for DMD cardiomyopathy, showing improved cardiac function and survival in mouse models and safety in canine models.

Hedgehog signaling via its ligand DHH acts as cell fate determinant during skeletal muscle regeneration

This study identifies DHH as a key ligand in the Hedgehog signaling pathway that regulates fibro/adipogenic progenitor fate during skeletal muscle regeneration, preventing adipogenesis and promoting fibrosis.

NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1

This study shows NF-κB interacts with BMAL1 to regulate circadian clock function through transcriptional repression at E-box elements.