This study develops a chronic TBI mouse model and finds that TBI leads to lifelong sleep/wake disturbances, circadian disruptions, and neuropathology.

Neurotrauma Reports · Jan 1, 2024Peer-reviewedNeuroscience

Defining the age-dependent and tissue-specific circadian transcriptome in male mice

Christopher A. Wolff, Miguel A. Gutierrez‐Monreal, Lingsong Meng, Xiping Zhang, Lauren G. Douma, Hannah M. Costello, Collin M. Douglas, Elnaz Ebrahimi, Ann T. Pham, Aline Cristina da Silva Oliveira, Chunhua Fu, Amy Nguyen, Bryan R. Alava, Stuart J. Hesketh, Andrew R. Morris, , Karyn Ann Esser

This study identifies age-dependent and tissue-specific changes in the circadian transcriptome of male mice, showing reduced rhythmic gene expression and increased variability in aged tissues.

Cell Reports · Jan 1, 2023Peer-reviewedGenomics

Machine learning approaches to identify sleep genes

Yin Yeng Lee, Mehari Endale, Gang Wu, Marc D. Ruben, Lauren J. Francey, Andrew R. Morris, Natalie Y Choo, Ron C. Anafi, David F. Smith, Andrew C. Liu, John B. Hogenesch

This study uses machine learning to predict sleep-related genes from genomic data and validates the NF-κB pathway's role in sleep duration in mice.

SLEEP · Dec 3, 2022Peer-reviewedGenomics

NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1

Yang Shen, Mehari Endale, Wei Wang, Andrew R. Morris, Lauren J. Francey, Rachel L. Harold, David W. Hammers, Zhiguang Huo, Carrie L. Partch, John B. Hogenesch, Zhao‐Hui Wu, Andrew C. Liu

This study shows NF-κB interacts with BMAL1 to regulate circadian clock function through transcriptional repression at E-box elements.

PLoS Genetics · Nov 22, 2021Peer-reviewedMolecular Biology