Gucan Dai

This study investigates how cholesterol modulates HCN channels in DRG neurons through sequential membrane remodeling, showing distinct effects in naive and neuropathic conditions.

The paper identifies intermediate voltage-sensor conformations in hERG channels caused by LQTS-associated mutations using FLIM, tmFRET, and MD simulations.

The paper proposes an allosteric model for electromechanical coupling in cardiac CNBD channels, explaining biphasic activation behaviors through voltage-sensor transitions and conformational coupling modes.

This study identifies RhoA's role in modulating ordered membrane domains (OMDs) under stress, linking cytoskeletal changes to membrane mechanics and neuropathic pain.