Guy S. Jacobs

Rapid convergence toward an agriculturalist regulatory landscape following lifestyle transition in Bornean hunter-gatherers

This study shows that a recent lifestyle shift to agriculture in Bornean Punan people rapidly alters their transcriptome and DNA methylation, resembling agriculturalists more than their foraging relatives.

From sporulation to village differentiation: the shaping of the social microbiome over rural-to-urban lifestyle transition in Indonesia

The paper presents a gut microbiome dataset from Indonesia, revealing novel species and subspecies linked to rural-to-urban lifestyle transitions and showing that community-level diet differences drive microbiome divergence.

Genetic architecture of gene regulation in Indonesian populations identifies QTLs associated with local ancestry and archaic introgression

The paper identifies Indonesia-specific eQTLs and methylQTLs linked to local ancestry and archaic introgression, showing their impact on gene regulation and hematological traits.

Denisovan introgression has shaped the immune system of present-day Papuans

The paper identifies Denisovan introgression in Papuan genomes that influences immune-related processes and regulatory elements, with experimental validation of functional impacts.

Characterisation of a second gain of function EDAR variant, encoding EDAR380R, in East Asia

The paper characterizes a second gain-of-function EDAR variant, EDAR380R, and finds it has increased signaling output but lacks the same signs of positive selection as EDAR370A.

Genome-wide DNA methylation and gene expression patterns reflect genetic ancestry and environmental differences across the Indonesian archipelago

The paper analyzes DNA methylation and gene expression in Indonesian populations to show genetic ancestry, environmental influences, and immune-related differences across regions.