Isabel Nocedal

This paper develops compact adenine base editors for in vivo gene editing, demonstrating their application in Duchenne muscular dystrophy by enabling exon skipping through targeted splice-site disruption.

DecoderTCR improves TCR-pMHC interaction prediction using pretraining and entropy-guided decoding, achieving high AUROC scores without epitope-specific training.

This study reports cryo-EM structures of Cas9d, revealing its DNA targeting mechanism and demonstrating a compact variant with robust nuclease activity in mammalian cells.