Christopher T. Brown

Compact adenine base editors to enable therapeutic rescue of Duchenne muscular dystrophy

This paper develops compact adenine base editors for in vivo gene editing, demonstrating their application in Duchenne muscular dystrophy by enabling exon skipping through targeted splice-site disruption.

Comparative characterization of Cas12f orthologs reveals mechanistic features underlying enhanced genome editing efficiency

The paper compares Cas12f orthologs to identify mechanistic features that enhance genome editing efficiency in human cells.

DNA targeting by compact Cas9d and its resurrected ancestor

This study reports cryo-EM structures of Cas9d, revealing its DNA targeting mechanism and demonstrating a compact variant with robust nuclease activity in mammalian cells.

dRep: A tool for fast and accurate genome de-replication that enables tracking of microbial genotypes and improved genome recovery from metagenomes

dRep groups genomes with fast Mash distances, then accurate ANI, de-replicating 1,125 infant gut genomes in 92 CPU hours versus 2,784 for naive gANI.